STABLE INTERNATIONAL ENVIRONMENTAL AGREEMENTS: LARGE COALITIONS THAT ACHIEVE LITTLE





Behavior of solvent-exposed hydrophobic groove in the anti-apoptotic Bcl-XL protein: clues for its ability to bind diverse BH3 ligands from MD simulations.

Bcl-XL is a member of Bcl-2 family of proteins involved in the regulation of intrinsic pathway of apoptosis.Its overexpression in many human cancers makes it an important target for anti-cancer drugs.Bcl-XL interacts with the BH3 domain of several pro-apoptotic Bcl-2 partners.This helical bundle protein has a pronounced hydrophobic groove which act

read more